GLOBAL CLIMATE CHANGE AND MOSQUITO-BORNE DISEASES

 

Theodore G. Andreadis

 

Department of Entomology and Center for Vector Biology and Zoonotic Diseases

The Connecticut Agricultural Experiment Station

123 Huntington St.

New Haven, CT06511

 

theodore.andreadis@ct.gov

ABSTRACT

World climate is in a warming phase that began in the early decades of 18th century and is occurring faster than any period in last thousand years.  Sea levels have risen approximately two mm per year, arctic sea ice has declined by 7.4% per decade, snow cover and glaciers have diminished in both hemispheres, and worldwide hydrological cycles are accelerating resulting in an increased intensity, frequency and duration of droughts, heavy precipitation events and flooding.  Observed climatic changes in North America alone have included fewer cold days and nights, more frequent heat waves and warm spells, more intense precipitation events, total rainfall and hurricanes, and increases in areas affected by drought.  Predictions from United Nations Intergovernmental Panel on Climate Change (IPCC) indicate that in next 90 years global temperature will increase between 1.8 oC and 4.0 oC and sea levels will rise by as much as two feet.

 

Mosquitoes, in their role as vectors, are critical components in the transmission cycle of many disease causing pathogens that affect hundreds of millions of people world-wide including Malaria, Dengue, Yellow Fever, Japanese Encephalitis, Chikungunya, Rift Valley Fever, West Nile virus and Filariasis.  Mosquitoes as well as the disease causing pathogens they transmit are directly impacted by changes in weather and climate.  Marginal changes in temperature, humidity and rainfall can have potentially large biological effects on disease transmission.  Since most mosquito-borne diseases are weather sensitive, have distinct seasonal patterns and occur in the tropics, it has been hypothesized that if warming heats up the global mosquito-borne diseases will expand into new regions and become more prevalent in areas where they already occur.

 

Climate change may affect the incidence of mosquito-borne diseases through its effect on four principal characteristics of vector mosquito populations that relate to pathogen transmission.

 

1.         Geographic and Temporal Distribution:  Range shifts in vector distribution that brings tropical mosquito vectors into contact with new susceptible human populations.  Temporal change would include an extension of the transmission season allowing mosquitoes to transfer pathogens for a longer period of time.

 

2.         Population Density:  Changes in the population density of the mosquito vector that result in an increased frequency of contact with humans.  This could arise from increased overwintering survival due to warmer temperatures, a shortening of larval development times, more frequent feeding by adults, quicker digestion of blood meals, and increased adult survival at higher latitudes.  Increased precipitation would increase the number and quality of larval breeding sites and epic rainfall events could synchronize mosquito host seeking and pathogen transmission.  An associated increase in humidity would further serve to increase mosquito survival.  Lower  rainfall amounts and draught conditions in other regions while generally decreasing the number and quality of larval breeding sites, could equally serve to create larval habitat by causing rivers to dry into “pools” that serve as production sites (eg. dry season malaria) and decreased rainfall would likely increase container-breeding mosquitoes by forcing increased water storage.

 

3.         Prevalence of Infection by Zoonotic Pathogens:  Changes in the prevalence of pathogen infection in the reservoir host or mosquito vector population that would increase the frequency of human contact with infected mosquito vectors

 

4.         Pathogen Load:  Changes in pathogen load brought about by changes in the rates of pathogen reproduction, replication, and development in the vector mosquito.  Increases in temperature would result in a decrease in the extrinsic incubation period of pathogen in the mosquito vector (i.e. the period of time from when a mosquito takes an infectious bloodmeal until it transmits the pathogen).  Pathogens inside the mosquito mature faster in heat, increasing transmission efficiency and the likelihood of the disease being spread.

 

Given this scenario, the greatest effects of climate change on transmission of mosquito borne diseases are likely to be observed at the temperature extremes of the range of temperatures at which transmission occurs, and effects are likely to be expressed in the increased frequency of short-term epidemics and long-term gradual changes in disease trends.  However it is important to recognize that climate change is only one of many factors affecting the incidence of mosquito-borne diseases.  Socioeconomic factors and human activities that impact the local ecology are equally important and may in fact have a greater impact.  These include demographic changes (population growth, migration, urbanization); societal changes (inadequate housing, water deterioration, migration); changes in public health policy (decreased resources for surveillance, prevention and vector control); insecticide and drug resistance; deforestation and irrigation systems and dams.

 

As noted by Reiter (Environmental Health Perspectives, 2001), “The natural history of mosquito-borne disease is complex and the interplay of climate, ecology and vector biology defies simplistic analysis.”  Adaptations to climate change and variability will largely depend on the level of health infrastructure in the affected regions.  We really don’t know how projected climate change will affect the complex ecosystems required to maintain these mosquito-borne diseases.  More research is needed to better understand the influence of weather and climate on these pathogens in their natural transmission cycles.  “Assessments that integrate global climate scenario-based analyses with local demographic and environmental factors will be needed to guide comprehensive, long-term preventive health measures” (Gubler et al. Environmental Health Perspectives, 2001).